
Project
Call for Partners | G-FORCE: GLP-1, Food-Origin Regulators and Appetite Control Effects
Pharmacological GLP-1 agonists (e.g., Ozempic) are transforming obesity treatment. These drugs drive significant weight loss with metabolic health benefits. However, this shift raises critical questions and concerns, but it also unlocks new scientific and commercial opportunities.
Within G-force, we aim to identify natural ingredients that enhance endogenous GLP-1 release and to gain a deeper understanding of their mechanisms of action. Partners are invited to contribute ingredients of interest for testing. We will employ state-of-the-art in vitro cell assays, receptor assays, and in vivo human clinical trials.
Based on these findings we will assess the satiating potential of a selection of food items. Our ultimate goal is to develop effective dietary strategies to support appetite regulation and reduce the risk of overeating. In addition, we will investigate whether GLP-1 agonist administration leads to shifts in food preferences and sensory perception. This will be explored within an existing prospective cohort designed to monitor health outcomes of obesity treatment. By gaining insight into how pharmacological GLP-1 treatment influences food preferences, we aim to better understand and respond to the evolving needs of this rapidly growing consumer group.
Partners
We invite industrial partners that are eager to stay at the forefront of developments in GLP-1 and satiation. This includes ingredient suppliers exploring GLP-1-stimulating potential of their ingredients and end-product manufacturers aiming to understand and respond to changing food preferences in individuals using pharmacological GLP-1 treatments, a rapidly growing consumer group.
This project will be submitted for Dutch Top sector AgriFood subsidy, which funds 50% of the project budget. The remaining 50% is contributed by industry via in cash and in kind contributions. Total project budget will range between €1.5–2.0 million. Partner contributions will range between €30,000–50,000 per year. This project will have a total duration of 4 years